Reset Apply. I am looking for. I am looking for Uric Acid Test. I am looking for allopurinol. I am looking for febuxostat. I am looking for lesinurad. I am looking for pegloticase. I am looking for xanthine oxidase inhibitor. I am looking for urate oxidase. I am looking for monosodium urate.
Study Description. This is a Phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy, safety, and pharmacokinetics study of 6 different dose regimens of ABP compared with placebo.
The study will consist of three sequential groups with escalating total daily ABP doses. Each dose group will have 3 stages following screening: Run-in, Dose Evaluation, and Follow-up. MedlinePlus related topics: Gout. FDA Resources. Arms and Interventions. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Inclusion Criteria: Subject is able to understand the study procedures, the risks involved and willing to provide written informed consent before the first study related activity. Subject must be willing to discontinue any other UA-lowering medication e. Exclusion Criteria: Subject with a documented history of rheumatoid arthritis or other autoimmune disease. Subject with any clinically significant hepatic, cardiovascular, renal, neoplastic, psychiatric illness, or hematological disorders such as polycythemia vera, sickle cell disease, or myelodysplastic disorder.
Subject with a history of alcohol or drug abuse within the past 1 year prior to screening, or current evidence of substance dependence or abuse. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.
Last Updated: December Minnesota Hmong are a unique population of individuals of South East Asian descent who have been noted to have a higher prevalence of gout and gout related comorbidities compared to non-Hmong. Elevated levels of uric acid are thought to be at the root cause of gout. Elevated levels of serum uric acid can result from either overproduction and or under-excretion. Xanthine oxidase plays a key role in the breakdown of purines to form uric acid. The objective of this study is to explore whether genetic variations in renal transporters may influence the disposition of serum uric acid in response to a drug allopurinol as well as the disposition of its active metabolite oxipurinol which may also be a substrate for these same transporters responsible for uric acid disposition.
Genetic variations unique to the Hmong population may explain their increased prevalence in gout and or perceived lack of responsiveness to the drug allopurinol used to treat the condition. MedlinePlus related topics: Gout. Drug Information available for: Allopurinol Allopurinol sodium.
FDA Resources. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
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